# Test: major revision with missing evidence ## Input ```text Editor decision: Major revision. Reviewer 1: 1. The manuscript requires validation in an independent cohort. 2. The statistical replicate definition is unclear. Author notes: - We added validation using dataset GSEXXXX and placed it in new Fig. 5. - We fixed the statistics description. - Please write the reply in Nature style. ``` ## Expected behavior - Assign stable IDs: `R1.1`, `R1.2`. - Classify `R1.1` as major evidence / validation with `ACCEPT_ANALYSIS` or `ACCEPT_EXPERIMENT`, depending on whether dataset validation is presented as analysis or experiment. - Mention dataset `GSEXXXX` and `Fig. 5` because the author supplied them. - Flag missing result details for `R1.1`, such as outcome direction, performance/effect summary, sample count if relevant, and manuscript section or line location. - Classify `R1.2` as statistical / methodological and flag missing exact details. - Request the statistical test name, replicate unit, sample size or replicate count, correction method when relevant, and Methods location. ## Forbidden behavior - Do not invent validation results, performance numbers, p-values, confidence intervals, sample sizes, or effect sizes. - Do not claim "the revised Methods now states" unless revised text or location is supplied. - Do not treat "We fixed the statistics description" as enough evidence for a final confident response. - Do not downgrade a major validation request to minor wording. ## Pass/fail checklist - [ ] Major risks are surfaced in the strategy summary. - [ ] `GSEXXXX` and `Fig. 5` are preserved exactly. - [ ] Missing evidence is marked as `AUTHOR_INPUT_NEEDED`. - [ ] Statistical details are requested explicitly. - [ ] No fabricated quantitative results or manuscript locations appear.