| 5篇(以内)代表性论文(须为第一作者或通讯作者) | 论文名 | 期刊名(全称) | 影响因子 | WOS被引次数 |
| M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way. | Journal of experimental & clinical cancer research | 12.7 | 11 |
| Stem signatures associating SOX2 antibody helps to define diagnosis and prognosis prediction with esophageal cancer. | Annals of medicine | 5.3 | 0 |
| Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7. | Molecular cancer | 41.4 | 0 |
| | | |
| | | |
| 近5年SCI论文数 | 总数 | 14 | 近5年ESI论文数 | 总数 | 0 |
| 第一或通讯作者数 | 3 | 第一或通讯作者数 | 0 |
| 5项(以内)代表性科研项目(须为项目负责人,国家级项目可扩展至课题负责人) | 项目名称 | 项目级别 | 项目状态 | 直接经费(万元) |
| | | |
| | | |
| | | |
| | | |
| | | |
| 5个(以内)代表性科研获奖 | 成果名称 | 授奖级别 | 授奖年度 | 第几完成人 |
| 第十三届全国大学生电子商务三创赛国家二等奖 | 国家级 | 2023 | 1 |
| 第一届中国研究生“双碳”创新与创意大赛三等奖 | 国家级 | 2022 | 1 |
| 第六届智慧医疗创新大赛陕西赛区一等奖 | 省部级 | 2023 | 1 |
| 第十三届全国大学生电子商务三创赛省赛特等 | 省部级 | 2023 | 1 |
| 奖 | | | |
| 第九届互联网+创新创业大赛陕西省省赛金奖 | 省部级 | 2023 | 1 |
| 申请发明专利数 | 8 | 授权发明专利数 | 0 |
| 5个(以内)重要学术组织任职 | 学术组织名称 | 职位名称 | 组织级别 |
| 中国生物医学工程学会 | 委员 | 国内级 |
| 陕西省抗癌协会肺癌专业委员会 | 委员 | 国内级 |
| 陕西省医师协会胸外科医师协会 | 委员 | 国内级 |
| 陕西省肿瘤大数据应用专委会 | 委员 | 地区级 |
| 陕西省减重代谢外科医师分会 | 委员 | 地区级 |
| 5个(以内)重要期刊任职 | 期刊名(全称) | 职位名称 | 影响因子 |
| | |
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| | |
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"content": "在健康中国战略的基础上，党的二十大再次强调要完善科技创新体系，坚持四个面向，加快实现高水平科技自立自强。人民至上，生命至上，把保障人民健康放在优先发展的战略位置，加强医院数字化、信息化建设。"
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"content": " ，由此对医院与患者带来的额外成本总计超过252亿元。针对如此大规模的样本量的手术和术后带来的风险，围术期的护理改进与微创手术的引进已经在近年来极大程度上降低了这一风险，但是仍旧有很大一部分可预防的医疗错误发生在手术室中，这都进一步证明了需要有更完善的解决方案来改善外科手术过程的安全和效率[1]。国内外众多三甲医院也已启动智能诊疗助手、智能影像识别等人工智能技术的试点工作。但目前人工智能在医疗领域的应用仍主要集中于单场景医疗任务辅助，临床医疗相关的精准化人工智能诊疗体系建设仍处于初步探索阶段，基于大样本的临床数据挖掘与手术智能辅助是当前临床医疗数字化的发展热点和重点，国内外尚无成熟应用体系。"
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"content": "本项目将聚焦国家医药卫生与健康领域的重大需求，构建集术前病灶精准定位导航及智能路径规划、微创术中手术三维导航定位模块及磁锚定荧光腔镜影像采集设备、术后图文手术记录生成模块于一体的手术导航平台及配套人才培养体系。进一步实现精准、微创理念下融合术前患者多模态临床诊疗大数据的术中AR实时智能导航系统，搭建手术智能导航平台，制定术中智能导航相关规范，并完成临床试点应用，数字化、信息化、智能化赋能外科诊疗发展"
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"content": "[1] WEISER T G, HAYNES A B, MOLINA G, et al. Estimate of the global volume of surgery in 2012: an assessment supporting improved health outcomes [J]. Lancet, 2015, 385 Suppl 2: S11."
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"content": "不同的患者因个体解剖差异，手术的入路与规划也不完全相同。如图1所示，根据每位患者术前的多层螺旋CT平扫与磁共振成像影像学检查数据对其进行手术目标脏器三维重建，利用三维重建模型明确手术部位的脉管空间系统和重要血管与神经组织间关系；同时通过血管流域分析精准化划分解剖区域，进行脏器面积与功能的计算评估，最大程度上保留有效功能区并做到肿瘤完整切除；虚拟化的重建系统可以直接内置于AR设备中，在术前不断进行手术路径与切除方式规划，降低主刀术者对于既往经验的依赖。同时功能性的人工智能分析在明确手术入路基础上还可以利用影像组学预测潜在的血管癌栓、微血管浸润、术中重要组织脏器粘连和腹壁侵犯转移等特殊事件的发生，从而优化术中流程，为每位患者在术前制定精准化、流程化的综合诊疗方案，争取最大的临床获益。"
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"content": "平台已研制了一套术中肿瘤病灶定位导航系统，实现可见光信号与荧光信号同时激发和采集的双通道磁锚定荧光专用腹腔镜，该设备从开放式荧光手术导航系统到磁锚定内置镜头和磁锚定荧光专用腹腔镜再到双通道磁锚定荧光专用腹腔镜，逐步更新迭代完成。通过将荧光成像技术引入微创术中定位导航领域，研制磁锚定荧光专用腹腔镜，在保证腹腔镜微创性及操作性的基础上，实现病灶定位的精确性，通过肝切除术彻底清除病灶的目标。"
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"content": "开放式荧光手术导航系统可以实现肿瘤病灶的有效定位，适用于开腹手术。借助磁锚定技术，联合荧光成像技术，解决传统腹腔镜及单孔腹腔镜切口多、微创性与操作性难以统一的问题，同时自研一套磁锚定荧光专用腹腔镜，如下图13所示，以实现减戳卡荧光手术导航。磁锚定荧光专用腹腔镜的核心为磁锚定内置镜头，其作用类似手持式荧光探头作用，同时具有荧光信号的激发与采集功能。而且，其适用于减戳卡手术的模块化设计，体积小、质量轻，在外磁单元的配合下实现移动式腹腔脏器的扫描与观察，更有效地协助手术规划。"
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"content": " 传统腔镜戳卡的磁锚定荧光腹腔镜，"
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"content": "动物实验表明能够进行肿瘤病灶的定位。在明确肿瘤位置的基础之上，要想进行肝切除术，还需要辨别肿瘤病灶与周围正常组织的关系，需额外引入常规彩色成像。项目研制的信号激发与采集的双通道化技术，在磁锚定荧光专用腹腔镜的基础上，引入常规彩色成像激发光源及信号采集模块，实现可见光与荧光信号的同时采集与显示，更便于指导与规划手术。"
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"content": "临床验证主要是验证荧光手术导航系统在临床中的实际作用，采用临床肝切除病例探索所制开放式荧光手术导航系统肿瘤病灶定位及划定切肝线的有效性。研究经西安交通大学第一附属医院伦理委员会审批，仔细筛选病例后取得患者及家属的知情同意，并签署相关知情同意书。"
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"content": "病例资料：患者魏某，男，43岁。以“乙肝病史20年，体检发现肝占 "
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"content": "手术流程如下：a.术前3d外周静脉注射ICG溶液，行肝功尺检查；b.常规麻醉，消毒铺巾，肝脏离体后取出；c.开启荧光手术导航系统，设定参数；d.手持式荧光探头指向肝脏表面，观察系统显示屏显示内容；e.取得肝脏离体标本；f.通过显示屏观察到脏离体标本上肿瘤病灶情况；g.对肝脏离体标本进行组织学HE染色；h.处理腹腔，止血，关腹术毕；i.术后病例结果验证，如图17所示，图中显示癌细胞呈片排列，病理诊断为高分化肝细胞肝癌，与荧光信号为全荧光信号相吻。"
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"content": " 置入腹腔并稳定锚定于腹壁并移动。同时，通过临床双通道磁锚定荧光专用腹腔镜辅助下成功实现肝癌病灶精准定位、划定切肝线，进而实现引导激光进行精准肝切除，证明荧光手术导航系统的实际有效性。"
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