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文档润色流和知识库构建流/claude-scholar/skills/nature-response/examples/major-revision-with-missing-evidence.md

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+# Example: major revision with missing evidence
+
+This synthetic example shows how to avoid fabricated compliance when an author note is incomplete.
+
+## Input
+
+```text
+Editor decision: Major revision.
+
+Reviewer 1:
+1. The manuscript requires validation in an independent cohort.
+2. The replicate definition in the statistical analysis is unclear.
+
+Author notes:
+- We added validation using dataset GSEXXXX in Fig. 5.
+- We fixed the statistics description.
+```
+
+## Expected handling
+
+```text
+Response strategy summary
+- Decision type: Major revision
+- Task mode: draft
+- Package readiness: needs_author_input
+- Major risks: validation results and statistical details are missing
+```
+
+The response may mention `GSEXXXX` and `Fig. 5` because they were supplied. It must not invent:
+
+- validation performance;
+- sample size;
+- p-values;
+- confidence intervals;
+- statistical test names;
+- Methods or Results line numbers.
+
+## Required author questions
+
+```text
+Missing information / risk flags
+- R1.1: Please provide the validation result summary, cohort size or dataset scale, and Results/Fig. 5 location.
+- R1.2: Please provide the statistical test name, replicate unit, sample size, correction method, and Methods location.
+```
+
+## Response style
+
+```text
+To address this concern, we added an independent validation analysis using dataset GSEXXXX,
+which is presented in Fig. 5. The final response requires the validation result summary and
+manuscript location before it can be marked ready_to_submit.
+```